Active learning aims to reduce expert labeling through man-machine interaction, while cost-sensitive active learning focuses on balancing labeling and misclassification costs. Based on Three-Way Decision (3WD) methodology and Label Uniform Distribution (LUD) model, a Cost-sensitive Active learning through the Farthest distance sum Sampling (CAFS) algorithm was proposed. Firstly, the farthest total distance sampling strategy was designed to query the labels of representative samples. Secondly, LUD model and cost function were used to calculate the expected sampling number. Finally, k-Means algorithm was employed to split blocks obtained different labels. In CAFS, 3WD methodology was adopted in the iterative process of label query, instance prediction, and block splitting, until all instances were processed. The learning process was controlled by the cost minimization objective. Results on 9 public datasets show that CAFS has lower average cost compared with 11 mainstream algorithms.